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Psychedelic Definition & Meaning Symptom assessment with the Yale-Brown Obsessive Compulsive Scale was carried out at 4, 8, and 24 hours after treatment. Marked decreases in symptoms were seen in all subjects during one or more sessions (23%–100% reduction in Yale-Brown Obsessive Compulsive Scale score), and most subjects with symptom reduction experienced relief beyond the expected pharmacological life of psilocybin, and beyond the 24-hour assessment. The authors suggest that their results warrant future studies using a traditional blinded, randomized, placebo-controlled trial to explore the efficacy and duration of effect from a more prolonged exposure to repeated doses of psilocybin in OCD patients. In subsequent studies, the Nichols group used a more receptor-selective psychedelic, DOI, to probe the role of the 5-HT2 receptor in fly behavior (Nichols, 2006; Johnson et al., 2009, 2011). Rather than starving and feeding as performed earlier, drug was mixed with the food substra